Evaporative Light Scattering detector is a good alternative for the detection of analytes with limited or no chromophores.
It is located immediately after the stationary phase of the LC column to detect compounds as they elute from the column.
Basically all compounds which are less volatile than the mobile phase can be detected. The method is based on three successive steps:
The presence of an analyte gives a response assumed to be proportional to the concentration. The instrument's response to the analyte in the unknown should be compared with the response to a standard.
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