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Physical-chemical properties

OECD 105

Water solubility

 The water solubility of a substance is the saturation mass concentration of the substance in water at a given temperature.

The test is preferably run at 20 ± 0,5 °C.

The column elution method is suitable for solubilities below 10-2 g/L. The test substance is eluted from a micro-column which is charged with quartz sand, previously coated with an excess of the test substance. The water solubility is given by the mass concentration of the eluate when this has reached a plateau as a function of time.

The flask method is suitable for solubilities above 10-2 g/L. Water is brought at a temperature above the test temperature and added with an excess of the test substance. When saturation is achieved, the mixture is cooled down to the test temperature and the mass concentration in the aqueous solution is measured.

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